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Multi-Parametric Surface Plasmon Resonance (MP-SPR)

 

Originally, surface plasmon resonance (traditional SPR) instruments have been developed for molecular interactions only. The technology has been used by pharma for more than 20 years with gold and dextran surfaces. Bionavis have pushed the limits of the technology to enable measurements on a number of other surfaces including polymers, graphene, nanoparticles and living cells.

 

More importantly, MP-SPR enables novel functions:

– Measurements of molecular interactions with PureKinetics™

– Measurements of layer properties with LayerSolver™

 

Life Science


Drug development (Drug formulation, Controlled drug release, Drug-cell interaction, Nanoparticle targeting, Uptake mechanisms)


Biophysics (Lipid interactions)


Process optimization and control (Production quality, Cell growth matrix)

Biosensors


Assay development (Agriculture, Food and feed safety, Environmental, Clinical, Border and Process control).


Development of point-of-care biosensors (EC, SERS, ELISA, fluorescence, printed biosensors, nanoparticles)

Material Sciences


New materials and coatings (Antimicrobial, Antireflective surfaces, Filter membranes, Contact lenses, Implants, Graphene, Carbon nanotubes, Green materials, Plasmonic materials,..)


Process optimization of thin film 

manufacturing (Display technologies, Solar cells, Batteries, ..)

• Unparalleled range: Optimize targeting from small molecule weight drugs up to nanoparticles and viruses
• Beyond affinity: Evaluate affinity as well as kinetics of the molecular binding events to provide decision tools for further selection
• Understanding: Understand better your molecules with kinetics and dynamic conformation change information from MP-SPR
• PureKinetics™: Bulk effect measured in-line ensuring premium quality data even with small molecules, lipids or biomaterials.
• Measurements from first selection of molecules up to uptake mechanisms: Quantify drug-material, drug-target, drug-lipid membranes and even drug-living cell monolayer interactions. Prove internalization label-free!
• No oil, no costly prism sensors: MP-SPR Navi™ instruments utilize optical RI matching elastomer and therefore, sensors are very easy to exchange and also to further analyze with other methods such as microscopy.

 

The Firsts of MP-SPR:


• The only SPR to provide absolute measurement of interaction kinetics as well as layer structural changes.
• First SPR instrument to distinguish trans- and para-cellular drug/nanoparticle transport on cell monolayer in real-time and label-free!
• The first SPR with an in-line bulk effect measurement (PureKinetics™)

• No costly assay transfer: develop your sensor directly on your sensing material: metals for electrochemical (EC) and SPR detection, plastics for ELISA, cellulose for printed biosensors, metal nanoparticles for SERS, glass for classical chemistry, magnetic nanoparticles, bacteria, living cells and more
• Any assay type: using direct binding, competitive assays, antibodies, fragments, DNA, molecularly imprinted polymers (MIPs), aptamers, nanoparticles, cells
• Any sample: Works with both gas and liquid samples, purified or crude, from small organic molecules up to metallic nanoparticles
• Easy validation: In-situ MP-SPR with electrochemistry, fluorescence, or other optical detection methods. Ex-situ: Microscopy.
• Beyond assay: Optimize also sample interaction with the disposable cartridge material to ensure binding only in the sensing area and not in the microfluidic channels.
• Understanding: Not just measurements, but unparalleled understanding of your assay kinetics and structural changes.

 

The Firsts of MP-SPR:


• The only commercial SPR providing absolute measurement!
• The widest range of sensing substrate materials in the market!
• The first SPR with an in-line bulk effect measurement (PureKinetics™)
• The first SPR to determine thickness and refractive index simultaneously (LayerSolver™)

• Material freedom: Characterize nanolayers of metals, ceramics, polymers, organic materials and even nanocellulose or graphene
• Nanolayers from Å to µm: Measure and quantify materials from the single layer up to micron-thick multilayers
• Nanoparticles: Optimize nanoparticles and their adsorption kinetics
• LayerSolver™: Quantify both key parameters – thickness and refractive index – simultaneously
• Separate the best from better: The most sensitive measurement for kinetics on surfaces – real-time kinetics of adsorption, swelling, release.
• Minimum sample preparation: No freezing, no cutting, just apply your thin film to our substrate.
• From dry to wet state with same configuration
• Easy validation: In-situ MP-SPR with electrochemistry, fluorescence, or other. Ex-situ: Thanks to oil-free operation, same sample can be measured with AFM or other techniques. In-silico: Results can be confirmed also analytically.
• In-situ and Ex-situ modification of sensors: Our wide range of substrates can be modified with almost any thin film deposition technique including self-assembly, Langmuir-Blodgett (LB), Chemical Vapour Deposition (CVD), Evaporation, Atomic Layer Deposition (ALD), Molecular imprinting, Spin coating, Dip coating and others.

 

The Firsts of MP-SPR:


• First commercial SPR for material sciences
• The most sensitive instrument to study biochemical properties of functional coatings.
• The only instrument to measure alternating nanolaminate thickness from 5Å, optical density and its barrier functionality.
• The first SPR to determine thickness and refractive index simultaneously (LayerSolver™)

Our Products

MP-SPR NaviTM 200 OTSO is entry level MP-SPR system making it ideally suited for teaching and educational purposes. Open design is optimal when auxiliary instruments are to be used.

Wider inner diameter of the flow-cell tubings and 6-sample automation makes MP-SPR NaviTM 210A VASA ideal for material characterization and nanoparticle research.

MP-SPR Navi™ 220A NAALI enables all the measurements as traditional SPR but provides premium quality data with PureKineticsTM and allows measurements of conformation changes. The instrument performs great also with direct measurements of small molecules.

MP-SPR NaviTM 400 KONTIO is specially designed to measure cell adhesion and cell-based interactions in physiologically relevant conditions. The instrument is compatible with complex cell culture media and other crude samples.

MP-SPR NaviTM 410A Karius is a powerful tool for both interaction studies and layer characterization, due to its simultaneous measurement in 4 channels combined with 7-sample automation. The instrument is compatible with complex matrices such as serum providing exceptional versatility for your research.

 

MP-SPR Navi™ 420A ILVES is an ideal solution for molecular interaction studies when high throughput is needed. Minimal dead volume with 4 liquid channels makes instrument optimal for small molecules interaction measurements.

How Can We Help?

If you require any further information on any of the Bionavis products, Please give us a call on +44 (0) 7977 926 418 or drop us an email at info@fintiedesolutions.com